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    COVID-19 Research: Study reveals New Details about Potentially Deadly Inflammation

    April 2, 2024, Categories  Biology/Biotechnology, Health/Medical

    COVID-19 research: New details about potentially deadly inflammation revealed in USC study
    SARS-CoV-2 NSP14 facilitates the activation of NF-κB signaling and inflammatory response. a, HEK293T cells were transfected with the plasmids of 27 SARS-CoV-2 proteins, along with MyD88 and a reporter plasmid carrying the NF-κB promoter (NF-κB-Luc) and the cells were analyzed for NF-κB activity by reporter gene assay. The horizontal dashed line indicates the activation level of the positive control (EV+MyD88) group. b, Expression of the proinflammatory genes TNFA, IL1B, IL6 and IL8 in human MDMs transfected with NSP14-specific or scramble control (Ctrl) siRNA, followed with SARS-CoV-2 infection at MOI = 1 for 48 h. c, Expression of the proinflammatory genes from b in Dox-inducible SARS-CoV-2 NSP14-expressing THP-1 cells, measured after treatment with Dox (1 μg ml...
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