obesity tagged posts

Highlights
•Diurnal changes in hypothalamic TCPTP coordinate feeding with energy expenditure
•Feeding represses hypothalamic TCPTP to increase energy expenditure
•TCPTP inhibits insulin signaling in AgRP neurons to repress energy expenditure
•Insulin signaling in AgRP neurons increases the browning of white fat

Scientists at Monash University’s Biomedicine Discovery Institute have found a mechanism by which the brain coordinates feeding with energy expenditure, solving a puzzle that has previously eluded researchers and offering a potential novel target for the treatment of obesity. Obesity – a major risk factor for many diseases including cardiovascular disease, Type 2 diabetes, liver disease and several cancers – is at epidemic levels in Australia.

Researchers from the Metabolic D...

Highlights
•Plasma TMAO levels are elevated in type 2 diabetic patients
•Levels of the TMAO-producing enzyme FMO3 in adipose tissue correlate with obesity
•Pharmacologic and genetic inhibition of Fmo3 stimulates white adipose tissue beiging
•Inhibition of Fmo3 promotes resistance to obesity

Cleveland Clinic researchers showed that blocking a specific intestinal microbial pathway can prevent obesity and insulin resistance, as well as cause fat tissue to become more metabolically active. The team, led by J. Mark Brown, Ph.D...

Intrahepatic IFN-I signaling and responsive CD8+ T cells promote metabolic disease in mice and correlate to worsened NAFLD in humans.

A high-fat diet and obesity turn “hero” virus-fighting liver immune cells “rogue”, leading to insulin resistance, a condition that often results in type 2 diabetes, according to research published today in Science Immunology. Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8+ T cells, white blood cells in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease-driving cells.

Scientists have been trying for many years to discover why the liver continues to pump out too ...

This image shows the impact of saturated fatty acids on the liver, muscles and fatty tissue. Credit: © DDZ

The global proliferation of overweight and obese people and people with type 2 diabetes is often associated with the consumption of saturated fats. Scientists at the German Diabetes Center and the Helmholtz Center in Munich (HMGU) have found that even the one-off consumption of a greater amount of palm oil reduces the body’s sensitivity to insulin and causes increased fat deposits as well as changes in the energy metabolism of the liver. The results of the study provide information on the earliest changes in the metabolism of the liver that in the long term lead to fatty liver disease in overweight persons as well as in those with type 2 diabetes.

DZD researchers working at the Germa...