Omega-3 tagged posts

An omega-3 paradox: When ‘healthy fats’ shut down defenses against cancer

salmon
Credit: Unsplash/CC0 Public Domain

Omega fatty acids have long been recognized for their benefits: supporting cardiovascular health, reducing systemic inflammation, and promoting brain development and cognitive function. But scientists now warn of a long-unrecognized downside to these compounds when it comes to cancer and immunotherapy.

New preclinical experiments by medical investigators in the Vascular Biology and Therapeutic Program at Yale University School of Medicine show that omega fatty acids can blunt the cancer-killing capabilities of the immune system’s natural killer cells.

Their research is part of a growing body of evidence suggesting that well-known—and largely beneficial—fatty acids can circumvent the body’s defenses and promote cancer growth.

A unifying he...

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An Omega-3 that’s Poison for Tumors

UCLouvain researchers used a 3D tumour cell culture system, called spheroids. In the presence of DHA, spheroids first grow and then implode. 

3D tumors that disintegrate within a few days thanks to the action of a well-known omega-3 (DHA, found mainly in fish) – this is a promising discovery. Hungry for fatty acids, tumor cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die.

So-called “good fatty acids” are essential for human health and much sought after by those who try to eat healthily. Among the Omega-3 fatty acids, DHA or docosahexaenoic acid is crucial to brain function, vision and the regulation of inflammatory phenomena.

In addition to these virtues, DHA is also associated with a reduction in ...

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