Category Health/Medical

The first 3D Map of the Heart’s Neurons

This image shows a whole-heart view of the 3D reconstructed male rat heart, showing the distribution of the heart’s neurons in yellow

The normal functioning of our hearts is maintained by our body’s control center—the brain—via an intricate network of nerves. When this communication is disrupted, it results in heart disease, including heart attacks, sudden cardiac death and problems in blood supply. As an added layer of safety, the heart has its own ‘little brain’, called the intracardiac nervous system (ICN) to monitor and correct any local disturbances in communication. The ICN is essential in supporting heart health and can even protect cardiac muscle during a heart attack...

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How a Protein can Inhibit Cancer Development in Mice

Researchers' illustration of the results
The researchers’ illustration of PP2A binding to ADAM17 which cleaves other proteins such as the growth factor EGF which again binds the receptor EGFR and stimulates cell growth.

In a new study, researchers have discovered how the protein PP2A can inhibit tumor growth in mice. The protein turns off an enzyme that stimulates cell growth, thus inhibiting the development of cancer.

Proteins are found throughout our cells and regulate a lot of biological processes that are important forour survival. But some of them also regulate processes that can make us sick. Now, an international research team, with researchers from the University of Copenhagen at the forefront, has achieved a much better understanding of one such protein.

In a new study, the researchers discovered how the protei...

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New Urine Testing method holds promise for Kidney Stone sufferers

image of droplets
A bioinspired technology enables machine-free droplet manipulation for potential rapid diagnostic urine testing for kidney stone patients.
 IMAGE: IMAGE PROVIDED BY PAK KIN WONG

Simpler test that can be done in doctor’s office offers results in 30 minutes. An improved urine-testing system for people suffering from kidney stones inspired by nature and proposed by researchers from Penn State and Stanford University may enable patients to receive results within 30 minutes instead of the current turnaround time of a week or more.

Kidney stones occur due to buildup of certain salts and minerals that form crystals, which in turn stick together and enlarge to form a hard mass in the kidneys...

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A ‘Switch’ that turns Autoimmunity Drugs into powerful Anti-Cancer Treatments

CCI

Scientists from the Antibody and Vaccine group at the University of Southampton have discovered a way to transform antibody drugs previously developed to treat autoimmunity into antibodies with powerful anti-cancer activity through a simple molecular “switch.”

This work, published in the journal Cancer Cell, focuses on a molecule called CD40 which is present on the surface of immune cells and controls both autoimmunity and cancer. In autoimmunity, CD40 is thought to be over-stimulated, increasing the chance of the immune system attacking healthy tissues; whereas in cancer, CD40 is believed to be under-stimulated, enabling tumour cells to evade the immune system. Targeting of CD40 with antibody drugs is ongoing in therapeutic interventions for both diseases.

Accordingly, antibody...

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