Category Health/Medical

Rresearchers at University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System report that accumulating amyloid – an abnormal protein linked to neurodegenerative conditions such as Alzheimer’s disease (AD) – occurred faster among persons deemed to have “objectively-defined subtle cognitive difficulties” (Obj-SCD) than among persons considered to be “cognitively normal.”

Classification of Obj-SCD, which has been previously shown to predict progression to mild cognitive impairment (MCI) and dementia, is determined using non-invasive but sensitive neuropsychological measures, including measures of how efficiently someone learns ...

Grizzly bears spend many months in hibernation, but their muscles do not suffer from the lack of movement. In the journal Scientific Reports, a team led by Michael Gotthardt reports on how they manage to do this. The grizzly bears’ strategy could help prevent muscle atrophy in humans as well.

A grizzly bear only knows three seasons during the year. Its time of activity starts between March and May. Around September the bear begins to eat large quantities of food. And sometime between November and January, it falls into hibernation...

“We’re facing a tremendous epidemic with teen anxiety and depression, and we wanted to find an early marker that predicted the development of anxiety, depression and attentional symptoms,” said the study’s lead author, Susan Whitfield-Gabrieli. She’s a professor of psychology and director of the Northeastern University Biomedical Imaging Center, in Boston.

In a small sample of less than 100 children without known mental health concerns, the research team found that connections in certain areas of the brain seen at age 7 could help predict mental health concerns that developed four years later.

“The study could have great clinical implications,” Whitfield-Gabrieli said...

Novel spinal therapy/delivery approach prevented disease onset in neurodegenerative ALS disease model in adult mice and blocked progression in animals already showing disease symptoms.

Writing in Nature Medicine, an international team headed by researchers at University of California San Diego School of Medicine describe a new way to effectively deliver a gene-silencing vector to adult amyotrophic lateral sclerosis (ALS) mice, resulting in long-term suppression of the degenerative motor neuron disorder if treatment vector is delivered prior to disease onset, and blockage of disease progression in adult animals if ...