Category Health/Medical

Fat-Dissolving Bile Acids may help regulate Gut Immunity and Inflammation

fat cells in stomach
The acids that break down fat in our intestines may also play a role in gut immunity and inflammation
Image: Ugreen/iStock / Getty Images Plus

Could bile acids—the fat-dissolving juices churned out by the liver and gallbladder—also play a role in immunity and inflammation? The answer appears to be yes, according to two separate Harvard Medical School studies published in Nature.

The findings of the two studies, both conducted in mice, show that bile acids promote the differentiation and activity of several types of T cells involved in regulating inflammation and linked to intestinal inflammatory conditions. They also reveal that gut microbes are critical for converting bile acids into immune-signaling molecules.

The work suggests possible therapeutic pathways for modulating ...

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New Radiotracer offers opportunities for Earlier Intervention after Heart Attack

 Binding specificity test. (A) PET/CT axial views, autoradiographs, and corresponding H&E stainings of 10-micron cross-sections prepared from MI nonblocked, blocked, and sham-operated rats. Autoradiographs and H&E stainings from nonblocked hearts show increased Ga-68-FAPI-04 uptake in infarcted area at 7 days after MI, whereas uptake is negligible after sham operation or injection of nonlabeled FAPI-04 (blocked). Infarcted areas in H&E stainings are identified with arrows. (B) PET image–derived infarct-to-noninfarct uptake ratio (derived from 6 nonblocked and 3 blocked rat hearts subjected to coronary ligation). (C) Autoradiography image–derived infarct-to-noninfarct uptake ratio (derived from 3 nonblocked and 3 blocked MI hearts). QL = quantum level.

New radiotracer offers opp...

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Alzheimer ‘Tau’ protein far surpasses Amyloid in predicting toll on brain tissue

Brain MRI scans
Tau PET brain scans (green) in early clinical-stage Alzheimer’s patients accurately predict the location of brain atrophy measured by MRI 1–2 years later (magenta). Amyloid PET imaging (blue) does not predict the location of either tau or future brain atrophy.

Tau PET brain imaging could launch precision medicine era for Alzheimer’s disease. Brain imaging of pathological tau-protein “tangles” reliably predicts the location of future brain atrophy in Alzheimer’s patients a year or more in advance, according to a new study by scientists at the UC San Francisco Memory and Aging Center...

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UNC expert helps treat Astronaut’s Blood Clot during NASA mission

Stephan Moll, M.D., at NASA.
CREDIT
UNC School of Medicine

“My first reaction when NASA reached out to me was to ask if I could visit the International Space Station (ISS) to examine the patient myself,” said Stephan Moll, MD, UNC School of Medicine blood clot expert and long-time NASA enthusiast. “NASA told me they couldn’t get me up to space quickly enough, so I proceeded with the evaluation and treatment process from here in Chapel Hill.”

Moll was the only non-NASA physician NASA consulted when it was discovered that an astronaut aboard the ISS had a deep vein thrombosis (DVT) – or blood clot—in the jugular vein of their neck...

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