Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues. Their findings suggest a more precise approach is required to potentially expand JAK inhibitor use to a wider range of allergy and inflammatory disorders. Details on the findings were published in the December 21, 2023, issue of the journal Cell.

JAK1 is a key protein in the body that supports cell communication and controls the immune system.

It is part of a group of proteins that pass signals ...

A research team at Osaka Metropolitan University has fabricated a gallium nitride (GaN) transistor using diamond, which of all natural materials has the highest thermal conductivity on earth, as a substrate, and they succeeded in increasing heat dissipation by more than 2X compared with conventional transistors. The transistor is expected to be useful not only in the fields of 5G communication base stations, weather radar, and satellite communications, but also in microwave heating and plasma processing.

Researchers at Osaka Metropolitan University are p...

There are few things more peaceful and relaxing than a night under the stars. Through the holidays, many people head away from the bright city lights to go camping. They revel in the dark skies, spangled with myriad stars.

As a child, I loved such trips, and they helped cement my passion for the night sky, and for all things space.

One of my great joys as an astronomer is sharing the night sky with people. There is something wondrous about helping people stare at the cosmos through a telescope, getting their first glimpses of the universe’s many wonders. But we can also share and enjoy the night sky just with our own eyes—pointing out the constellations and the planets or discovering the joys of watching meteor showers.

It is easy to be bitten by the astronomy bug, and a co...

The therapy—developed at the University of Nebraska Medical Center (UNMC)—relies on both the immune system to fight key aspects of Alzheimer’s, plus modified cells that zero in on the brain protein plaques that are a hallmark of the disease.

In patients with Alzheimer’s, amyloid-beta protein forms plaques that prevent nerve cells from signaling each other. One theory is that this might cause irreversible memory loss and behavior changes characteristic of Alzheimer’s disease.

The new study was recently published in the journal Molecular Neurodegeneration. Researchers used genetically modified immune-controlling cells called Tregs to target amyloid-beta.

When the UNMC te...