Neuropathic pain – abnormal hypersensitivity to stimuli – is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV.

In a paper published in the journal Neuron, researchers report that a mechanism involving the enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord both initiates and maintains neuropathic pain. Moreover, they show that targeting spinal Tiam1 with anti-sense oligonucleotides injected into the cerebrospinal fluid effectively alleviated neuropathic pain hypersensitivity.

“Thus, our study has uncovered a pathophysiological mechanism that initiates, ...

DNA archival storage within reach thanks to new PCR technique. Storing data in DNA sounds like science fiction, yet it lies in the near future. Professor Tom de Greef expects the first DNA data center to be up and running within five to ten years. Data won’t be stored as zeros and ones in a hard drive but in the base pairs that make up DNA: AT and CG. Such a data center would take the form of a lab, many times smaller than the ones today. De Greef can already picture it all. In one part of the building, new files will be encoded via DNA synthesis. Another part will contain large fields of capsules, each capsule packed with a file. A robotic arm will remove a capsule, read its contents and place it back.

We’re talking about synthetic DNA...

Earth will meet a similar fate in 5 billion years. As a star runs out of fuel, it will billow out to a million times its original size, engulfing any matter — and planets — in its wake...

When Edwin Hubble observed distant galaxies in the 1920s, he made the groundbreaking discovery that the universe is expanding. It was not until 1998, however, that scientists observing Type Ia supernovae further discovered that the universe is not just expanding but has begun a phase of accelerating expansion. “To explain this acceleration, we need a source,” says Joseph Mohr, astrophysicist at LMU...