Oxygen Restriction helps Fast-Aging Lab Mice Live Longer

lab mouse
Credit: Pixabay/CC0 Public Domain

For the first time, researchers have shown that reduced oxygen intake, or “oxygen restriction,” is associated with longer lifespan in lab mice, highlighting its anti-aging potential. Robert Rogers of Massachusetts General Hospital in Boston, US, and colleagues present these findings in a study published May 23rd in the open access journal PLOS Biology.

Research efforts to extend healthy lifespan have identified a number of chemical compounds and other interventions that show promising effects in mammalian lab animals— for instance, the drug metformin or dietary restriction. Oxygen restriction has also been linked to longer lifespan in yeast, nematodes, and fruit flies. However, its effects in mammals have been unknown.

To explore the anti-aging...

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Researchers develop Calcium Rechargeable Battery with Long Cycle Life

Schematic of a prototype Ca metal battery. The battery comprises a Ca2+ storing positive electrode containing the CuS cathode and Ca metal anode with a hydrogen cluster electrolyte. Cycling performance of the Ca-CuS battery. Credit: Kazuaki Kisu

A research group has developed a prototype calcium (Ca) metal rechargeable battery capable of 500 cycles of repeated charge-discharge—the benchmark for practical use.

The breakthrough was reported in the journal Advanced Science on May 19, 2023.

With the use of electric vehicles and grid-scale energy storage systems on the rise, the need to explore alternatives to lithium-ion batteries (LIBs) has never been greater. One such replacement is Ca metal batteries...

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The Laws of Physics have Not Always been Symmetric, which may explain why you exist

cosmos
Credit: Pixabay/CC0 Public Domain

For generations, physicists were sure the laws of physics were perfectly symmetric. Until they weren’t.

Symmetry is a tidy and attractive idea that falls apart in our untidy universe. Indeed, since the 1960s, some kind of broken symmetry has been required to explain why there is more matter than antimatter in the universe—why, that is, that any of this exists at all.

But pinning down the source behind this existential symmetry violation, even finding proof of it, has been impossible.

Yet in a new paper published in Monthly Notices of the Royal Astronomical Society, University of Florida astronomers have found the first evidence of this necessary violation of symmetry at the moment of creation...

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Titanium Dioxide: E171 first enters the Blood via the Mouth

Titanium dioxide: E171 first enters the blood via the mouth
Correlative secondary electron (SE) imaging, scanning transmission ion microscopy (STIM) and secondary ion mass spectrometric (SIMS) elemental mapping of ultrathin sections of buccal TR146 cells exposed to food-grade TiO2 (E171) particles for 24 hours. In contrast to the TEM images presented in figure 2, SE imaging obtained with a helium ion microscope (here, npSCOPE) reveals predominantly topographical information. The thin sections therefore show only limited contrast of the cell structures and the nanoparticles are easily recognized. For TEM-like imaging, the STIM detector attached to the npSCOPE prototype device allows investigation of the transmitted beam information and highlights the NP in relation to the cellular ultrastructure...
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